NR2B antagonists and disease
- VernacularTitle:NMDA受体亚单位NR2B拮抗剂和神经退行性疾病
- Author:
Haiyan PENG
;
Junrong DU
- Publication Type:Journal Article
- Keywords:
NMDA receptor, neurodegenerative diseases, NR2B antagonists
- From:
Chinese Pharmacological Bulletin
1986;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
NMDA receptor has shown to be involved in several central nervous system disorders such as stroke, pain, parkinson′s disease, Huntington′s disease and epilepsy. Early studies revealed that NMDA antagonists produced adverse side effect that hampered the effort to develop NMDA antagonists. With advances in understanding the structure of NMDA receptor, NR2B antagonist is expected to be a more effective candidate with little side effect to treat these diseases. Several NR2B antagonists including CP 101, 606 are in preclinical trials in foreign countries. The present review summarizes progress in pharmacological actions of NR2B antagonists on neurodegenerative diseases.
