Effect of maternal ethanol consumption during gestation on insulin sensitivity and adipokines in the rat offspring
- VernacularTitle:孕鼠大量酒精摄入对子代胰岛素敏感性及脂肪源性细胞因子的影响
- Author:
Zhuo SHI
;
Jibing QU
;
Jing LI
;
Fengying GUAN
;
Li CHEN
- Publication Type:Journal Article
- Keywords:
ethanol;
insulin resistance;
leptin;
resistin;
adiponectin;
intrauterine growth restriction
- From:
Chinese Pharmacological Bulletin
1986;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Aim To investigate the effect of prenatal alcohol on insulin sensitivity of rat offspring and its underlying mechanism. Methods Female Sprague Dawley rats were given ethanol 4 g?kg-1?d-1 by gavage throughout pregnancy. At 16 wk of age, the rat offsrping underwent intravenous glucose tolerance test. The mRNA level of adipose leptin, resistin and adiponectin were determined by RT-PCR. Serum leptin, resistin and adiponectin were measured with RIA kits. Results Newborn ethanol rats had lower birth weight than control [(5.7?0.1) g vs (6.9?0.1) g,P
