Protective effect of extract of astragalus against injury induced by amyloid peptide in hippocampal neuron
- VernacularTitle:黄芪提取物保护A?致海马神经元损伤
- Author:
Dongmei LIU
;
Dongfang XU
;
Zhijuan LIU
;
Yaping FANG
;
Yuyou YAO
;
Weiping LI
- Publication Type:Journal Article
- Keywords:
AST;
A?_25-35;
hippocampal neurons injury
- From:
Chinese Pharmacological Bulletin
1986;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Aim To study the effect of EA on the injury induced by ?-amyloid protein(A?) in primary cultures of rat hippocampal neurons. Methods The protective effect of EA on A?_25-35 induced neurons injury was observed by LDH release rate, MTT, LSCM and TUNEL. Results A?_25-35 could induced cell death in rat primary hippocampal neurons. Four hours pretreatment with 20 mg?L-1, 40 mg?L-1 EA exerted the protective effect on rat primary hippocampal neurons from A?_25-35 induced injury. Conclusion EA had protective effects against injury induced by A?_25-35 in rat primary hippocampal neurons to some certain,which probably related with decreasing the level of calcium.
