Expression of suppressor of cytokine signaling 2 in breast carcinoma by tissue microarray
- VernacularTitle:细胞因子信号转导抑制因子2在乳腺癌中的表达
- Author:
Yuzhao ZHU
;
Qiong ZHANG
;
Yang WANG
;
Weiqiang ZHENG
- Publication Type:Journal Article
- Keywords:
supressors of cytokine signaling;
breast neoplasms;
microarray analysis
- From:
Academic Journal of Second Military Medical University
1981;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the expression of suppressor of cytokine signaling 2 (SOCS2) in breast carcinoma tissues and to discuss its relationship with clinical pathological data of breast carcinoma patients. Methods: The tissue microarray for 171 cases of breast carcinoma specimens, 18 adjacent tissues and 20 breast benign lesions were established. Then the expression of SOCS2, ER, PR, cerbB2, p53 and Ki-67 was detected by tissue microarray technique and S-P immunohistochemistry. Results: Positive rates of the SOCS2 protein in the breast carcinoma specimens, adjacent tissues and breast benign lesion were 57. 89% (99/171), 94. 44% (17/18), and 75% (15/20), respectively. The expression of SOCS2 was significantly different in breast carcinoma tissues of different TNM classification, different histological grades, and with or without Ki-67 expression and lymphatic metasrasis(P
