Influence of edaravone on MDA and expression of Hsp-70 and Bcl-2 in the perihematoma region in rats.
- VernacularTitle:依达拉奉对大鼠脑血肿周围组织丙二醛热休克蛋白-70及Bcl-2基因表达影响的研究
- Author:
Lin YIN
;
Xiaofeng QIU
;
Sujie CHANG
- Publication Type:Journal Article
- Keywords:
Intracerebral hemorrhage;
Apoptosis;
Edaravone
- From:
Chinese Journal of Practical Internal Medicine
2002;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the influence of edaravone on malondialdehyda(MDA)and expression of Hsp-70 and Bcl-2 in the perihematoma region in rats.Methods A total of 120 health male rats were randomly divided into false-operation group(n=20)、intracerebral hemorrhage(ICH)-therapy group(n=50)and ICH control group.Each group was further divided into 5 subgroups respectively according to 6 h、24 h、48 h、72 h and 5d after model creation.Cerebral hemorrhage model was duplicated with the method created by Fredrik.Brain water content and MDA were measured.Expression of Hsp-70 and Bcl-2 were assayed in each group with immunohistochemical method.Results Brain water content and MDA were lower in ICH-therapy group than those in control group(P
