Effect of Ambroxol on NF-?B activation of macrophage in the induced sputum in chronic obstructive pulmonary disease.
- VernacularTitle:盐酸氨溴索对慢性阻塞性肺疾病诱导痰巨噬细胞NF-?B的影响
- Author:
Yong QI
;
Yuepeng GUO
;
Jizhen WU
- Publication Type:Journal Article
- Keywords:
Pulmonary disease,Chronic obstruction;
Ambroxol;
Nuclear factor-?B;
lnduced sputum
- From:
Chinese Journal of Practical Internal Medicine
2002;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of Ambroxol on NF?B activation of macrophage in the induced sputum in patients with stable COPD.Methods Induced sputum was taken from 47 stable COPD patients,who were divided into two groups randomly.Macrophages were collected,and NF-?B activation and IL-8 of induced sputum were determined by immunohistochemistry;SOD and MDA were determined synchronously.Results NF-?B activation in macrophage and IL-8 in the treated group were significantly decreased in patients of stable group than those in the controls.Conclusion Ambroxol can decrease NF-?B activation in macrophage in stable COPD patients.
