A retrospective study of single frozen-thawed blastocyst transfer.
10.5653/cerm.2016.43.2.106
- Author:
Yong Soo HUR
1
;
Eun Kyung RYU
;
Seung Hyun SONG
;
San Hyun YOON
;
Kyung Sil LIM
;
Won Don LEE
;
Jin Ho LIM
Author Information
1. Maria Fertility Hospital, Seoul, Korea. geaher@mariababy.com
- Publication Type:Original Article
- Keywords:
Blastocyst;
Single embryo transfer;
Vitrification
- MeSH:
Blastocyst*;
Embryo Transfer*;
Epithelium;
Female;
Humans;
Infertility;
Pregnancy;
Retrospective Studies*;
Single Embryo Transfer;
Vitrification
- From:Clinical and Experimental Reproductive Medicine
2016;43(2):106-111
- CountryRepublic of Korea
- Language:English
-
Abstract:
OBJECTIVE: To study the clinical outcomes of single frozen-thawed blastocyst transfer cycles according to the hatching status of frozen-thawed blastocysts. METHODS: Frozen-thawed blastocysts were divided into three groups according to their hatching status as follows: less-than-expanded blastocyst (≤EdB), hatching blastocyst (HgB), and hatched blastocyst (HdB). The female age and infertility factors of each group were evaluated. The quality of the single frozen-thawed blastocyst was also graded as grade A, tightly packed inner cell mass (ICM) and many cells organized in the trophectoderm epithelium (TE); grade B, several and loose ICM and TE; and grade C, very few ICM and a few cells in the TE. The clinical pregnancy and implantation rate were compared between each group. The data were analyzed by either t-test or chi-square analysis. RESULTS: There were no statistically significant differences in average female ages, infertility factors, or the distribution of blastocyst grades A, B, and C in each group. There was no significant difference in the clinical pregnancy and implantation rate of each group according to their blastocyst grade. However, there was a significant difference in the clinical pregnancy and implantation rate between each group. In the HdB group, the clinical pregnancy and implantation rate were similar regardless of the blastocyst quality. CONCLUSION: There was an effect on the clinical outcomes depending on whether the blastocyst hatched during single frozen-thawed blastocyst transfer. When performing single frozen-thawed blastocyst transfer, the hatching status of the frozen-thawed blastocyst may be a more important parameter for clinical outcomes than the quality of the frozen-thawed blastocyst.
