The effects of plasma low high-density lipoprotein cholesterol on platelet cytosolic free calcium and release reaction
- VernacularTitle:低高密度脂蛋白胆固醇血症对血小板胞浆游离钙及释放反应的影响
- Author:
Leiming LUO
;
Yanhan LI
;
Jinhui WANG
- Publication Type:Journal Article
- Keywords:
Lipoproteins,HDL;
Platelet cytosolic free calcium;
Beta-thromboglobulin;
Platelet factor 4
- From:
Chinese Journal of Practical Internal Medicine
2002;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To discuss pathogenic effects of low high-density lipoprotein cholesterol(HDL-C)on atherosclerosis and thromboembolism,the influences of HDL-C on platelet cytosolic free calcium concentration([Ca2+]i),platelet release reaction products beta-thromboglobulin(?-TG)and platelet factor 4(PF4)were observed in dyslipoproteinemia patients with low HDL-C.Methods i,?-TG and PF4 were measured by fluorescent probe Fura 2-AM and ELISA skills respectively,in 42 patients with low HDLC(LHDL-C)and 25 healthy controls(CONT).Results Compared with those in CONT group,the platelet[Ca2+]i,?-TG and PF4 were all higher in LHDL-C group(all P
