Changes of serum cytokines and their clinical significance in infants with cytomegalovirus infection
- VernacularTitle:细胞因子水平改变在婴儿巨细胞病毒感染中的临床意义
- Author:
Wan XIONG
;
Yu LIU
;
Qiong CHEN
;
Yang WU
- Publication Type:Journal Article
- Keywords:
cytomegalovirus infection;
tumor necrosis factor-?;
interferon-?;
interleukin-4
- From:Journal of Third Military Medical University
2003;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the changes of serum cytokines and explore their role in infants with cytomegalovirus (CMV) infection. Methods We recruited 41 positive CMV-IgM plus normal ALT infants (other disease group), 30 positive CMV-IgM plus abnormal ALT infants (hepatitis group) and 30 healthy infants (control group) in the study. The levels of tumor necrosis factor-?(TNF-?), interferon-?(IFN-?) and interleukin-4 (IL-4) in serum were measured with ELISA. The association between TNF-? and ALT was analyzed. Results The levels of TNF-?, IFN-?, IL-4 were higher, and IFN-?/IL-4 was significantly lower in the two CMV infection groups than the control group. Compared with other disease group, the changes of TNF-?, IL-4, and IFN-?/IL-4 showed significance in hepatitis group. The level of TNF-? showed a positive association with ALT in hepatitis group(r=0.76,P
