STUDY ON THE EFFECT OF PROPOLIS EXTRACTS ON ACUTE PLEURISY AND ITS MECHANISM IN RATS
- VernacularTitle:蜂胶提取液对大鼠急性胸膜炎的作用及其机制的研究
- Author:
Fuliang HU
;
Yinghua LI
;
Wei ZHU
;
Minli CHEN
;
Huazhong YING
- Publication Type:Journal Article
- Keywords:
propolis;
carrageenan;
acute pleurisy;
NO;
PGE_2
- From:
Acta Nutrimenta Sinica
1956;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the anti-inflammatory effect and the possible mechanism of water and ethanol extracts of propolis. Method: Forty male Wistar rats were divided into 5 groups: normal group, model group, medicine groups, two groups treated with water and ethanol extracts of propolis. The acute pleurisy model was established by injecting carrageenan. The effects of propolis on acute pleurisy was studied by counting leukocytes, measuring the content of MDA, lysozyme and activity of SOD in serum and the content of NO, protein and PGE2 in pleural effusion. Results: The propolis solutions extracted by water and ethanol presented obvious effect on inflammation. It could antagonize the purulent pleurisy, reduce the number of leukocytes and the content of MDA, lysozyme and activity of SOD in serum and the contents of NO, protein and PGE2 and decrease the inflammation. Conclusion: Propolis displays anti-inflammatory effects by decreasing the action of NO and PGE2 and preventing the activation of protein kinase.
