Risk Factors for Metachronous Recurrence after Endoscopic Submucosal Dissection of Early Gastric Cancer.
10.3346/jkms.2017.32.3.421
- Author:
Chang Su CHUNG
1
;
Hyun Sun WOO
;
Jun Won CHUNG
;
Seok Hoo JEONG
;
Kwang An KWON
;
Yoon Jae KIM
;
Kyoung Oh KIM
;
Dong Kyun PARK
Author Information
1. Division of Gastroenterology, Department of Internal Medicine, Gachon University, Gil Medical Center, Incheon, Korea. drgreen@gilhospital.com
- Publication Type:Original Article
- Keywords:
Gastric Cancer;
Endoscopic Submucosal Dissection;
Metachronous Recurrence
- MeSH:
Aged;
Helicobacter pylori;
Humans;
Incidence;
Methods;
Recurrence*;
Retrospective Studies;
Risk Factors*;
Stomach Neoplasms*
- From:Journal of Korean Medical Science
2017;32(3):421-426
- CountryRepublic of Korea
- Language:English
-
Abstract:
Although endoscopic submucosal dissection (ESD) is widely accepted as a curative treatment method for early gastric cancer (EGC) worldwide, metachronous recurrence often occurs after ESD for EGC. However, there are insufficient data about the role of Helicobacter pylori (H. pylori) infection and other risk factors for recurrence. We aimed to compare the metachronous lesion in the H. pylori persistent group and the eradicated group, and to identify risk factors for metachronous lesion. We retrospectively analyzed 782 patients who underwent ESD between January 2008 and December 2013. We excluded patients with dysplasia or patients who were not tested for H. pylori infection. One hundred eighty-five patients were enrolled. We studied risk factors for recurrence, and used survival analysis to test. There were 24 patients with metachronous recurrence after ESD for EGC among the group. The incidence of metachronous gastric lesions after ESD for EGC developed more in the over 70-year-old group (P = 0.025) and more in the H. pylori persistent group (P = 0.008). In conclusion, H. pylori infection and old age are independent risk factors for metachronous gastric lesions after ESD in EGC.
