Changes in IL-19 and antagonizing effects of meloxicam on endotoxin-induced acute lung injury in rabbits
- VernacularTitle:内毒素致兔急性肺损伤IL-19变化及美洛昔康的拮抗作用
- Author:
Jianxin WANG
;
Cuilian WENG
;
Qingliang XUE
- Publication Type:Journal Article
- Keywords:
acute lung injury;
endotoxins;
interleukin-19;
meloxicam
- From:
Medical Journal of Chinese People's Liberation Army
1981;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the changes in interleukin-19(IL-19)in lungs of rabbits with acute lung injury(ALI)induced by endotoxin(ET),so as to study the mechanism of injury of ET to the lung and the protective mechanism of meloxicam.Methods Twenty four male Japanese flap-eared white rabbit was randomly assigned to three groups:control group,ET-treated group and treatment with meloxicam group.Rabbit ALI model was replicated with intravascular ET injection(700?g/kg),and meloxicam was intravenously injected(2.5mg/kg)for treatment group.The content of IL-19 was measured with ELSIA method and the changes in malondialdehyde(MDA)and superoxide dismutase(SOD)were determined in every group.Results IL-19 expression in ET challenged group was significantly higher than that in control group(P
