Imipramine promotes regeneration of hippocampus neuron after traumatic brain injury in rat
- VernacularTitle:丙咪嗪对脑外伤后大鼠海马内神经元再生的促进作用
- Author:
Jun ZHANG
;
Bainan XU
;
Chong LI
- Publication Type:Journal Article
- Keywords:
brain injury;
imipramine;
nerve regeneration
- From:
Medical Journal of Chinese People's Liberation Army
1981;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the potential mechanism of efficacy of imipramine treatment in the regeneration of hippocampus neuron after traumatic brain injury in rat.Methods Lateral hydraulic battering injury(HBI)was used to induce acute brain injury in rats.Forty male SD rats were randomly assigned to four groups:HBI with imipramine treatment group,HBI without treatment group,sham injury with imipramine treatment group and sham injury without treatment group.Animals of all the four groups were sacrificed for histological evaluation two months after treatment.Proliferating cells and neurons in hippocampus were counted and compared between groups.Results Proliferating cells and neurons were found to be obviously increased in all injured rats compared with sham injured animals(P
