Reversal effect of verapamil on the drug resistance of NCI-H446 cell line induced by radiation
- VernacularTitle:维拉帕米对外照射导致的小细胞肺癌细胞系耐药性的逆转作用
- Author:
Peng SONG
;
Yunyou DUAN
;
Jianjun YANG
- Publication Type:Journal Article
- Keywords:
cell line,small cell lung cancer;
radiation;
verapamil;
drug screening assays,antitumor;
mitomycin
- From:
Medical Journal of Chinese People's Liberation Army
1981;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the reversal effect of verapamil on the drug resistance of NCI-H 446 small cell lung cancer cell line induced by fractionated radiation.Methods Exponentially grown NCI-H 446 cells were exposed to total radiation dose of 50 Gy,which was given in 25 fractions of 2 Gy per fraction.The survival rate of NCI-H 446 cell line,before and after fractional radiation,was observed after adding different concentrations of mitomycin C(MMC).The change in survival rate of NCI-H 446 cell line was also observed while verapamil was added additionally to the above.Results The survival rate of the radiated cell line was higher than that of the unradiated cell line under the same concentration of MMC(P0.05),or the survival rate of radiated cell line was obviously lower than that of unradiated cell(P
