Photodynamic therapy for cutaneous malignant tumor
- VernacularTitle:激光光动力疗法治疗皮肤恶性肿瘤的临床研究
- Author:
Huilong LIU
;
Duanqi LIU
;
Yahui JIE
- Publication Type:Journal Article
- Keywords:
skin neoplasms;
photochemotherapy;
photosensitizing agents;
lasers
- From:
Medical Journal of Chinese People's Liberation Army
1981;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study both therapeutic and adverse effects of photodynamic therapy for cutaneous malignant tumors.Methods The IEAu-3 gold vapor laser(wavelength 627.8nm),manufactured by the Institute of Electronics,Chinese Academy of Sciences,and diode laser(wavelength 630nm),manufactured by DIOMED Ltd.(GB),were employed as the light source.Power density of the both kinds of laser was 100-150mW/cm2,and energy density was 150-300J/cm2.Haematoporphyrin derivative(HpD)was used as pohotosensitizer at dosage of 5mg/kg.The patients' foci were radiated 12-72h after HpD administration.The patients received 1 to 4 courses of photodynamic therapy.The size of patients' focus was measured before and after treatment and the therapeutic effect was appraised 4 weeks later.Results Evaluation of the therapeutic effect in 30 patients showed that 15 patients(50.0%)responded completely(CR),10 patients(33.3%)responded partially(PR),and 5 patients(16.6%)showed no response(NR).No patients showed progression of the lesion(PD).The total response case(CR+PR)was 25.No adverse effect was found in this group.Conclusions Photodynamic therapy is an effective and safe modality for cutaneous malignant tumor especially for basal cell skin cancer and squamous cell skin cancer.
