Effect of lipid-lowering treatment on the function of B islet cells in the first-order relatives with normal glucose tolerance of type 2 diabetes mellitus
- VernacularTitle:2型糖尿病患者糖耐量正常一级亲属降脂治疗对胰岛B细胞功能的影响
- Author:
Mingwei CHEN
;
Minggong YANG
;
Youmin WANG
- Publication Type:Journal Article
- Keywords:
Diabetes mellitus,non-insulin-dependent;
Free fatty acid;
First degree relatives;
B-cell function
- From:
Chinese Journal of Practical Internal Medicine
2001;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the change of B-cell function after reduction in plasma free fatty acid(FFA)concentration.Methods All 38 normoglycemic first-degree relatives of type 2 diabetes received a 75 g oral glucose tolerance test(OGTT),before and after acipimox,250 mg orally tid for 5 days.Results Acipimox significantly reduced fasting plasma FFA,HOMA-IR,the incremental glucose area under the curve(AUCg)and the incremental FFA area under the curve(AUCf)during OGTT(P0.05).The increment in ?I30/?G30、?I30??G30-1?HOMA-IR-1 correlated negatively with the decrement in fasting FFA,AUCf(r=-0.39~-0.49,P
