Neuroprotective Actions and Possible Underlying Molecular Mechanisms of Valproate
- VernacularTitle:丙戊酸盐的神经保护作用及其机制的研究进展
- Author:
Lingyun LI
;
Zhenghong QIN
;
Zhongqin LIANG
- Publication Type:Journal Article
- Keywords:
valproate;
neuroprotection;
HDAC;
MEK/MAPK;
bcl-2
- From:
Chinese Pharmacological Bulletin
1987;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Valproate (VPA) has long been used for the treatment of bipolar mood disorder. VPA is effective in control of mania and depression. Recent studies have demonstrated that VPA has profound neuroprotective effects in against various apoptotic stimuli. Moreover, VPA can promote neurogenesis, neuronal proliferation and differentiation. Although intensive research has been dedicated to VPA′s neuroprotection, the molecular mechanisms by which VPA protects neurons are still not fully understood. In this paper, recent progresses in the study of VPA′s neuroprotection and underlying mechanism are reviewed.
