Effect of lead on calcium absorption and bone development in weanling rats
- VernacularTitle:铅对幼年大鼠钙的吸收和骨骼生长的影响
- Author:
Xueqin HU
;
Mantian MI
- Publication Type:Journal Article
- Keywords:
calcium;
lead;
femur;
osteocalcin;
parathormone;
45CaCl2 tracing
- From:Journal of Third Military Medical University
1988;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effect of lead on the calcium absorption and bone development in weanling rats. Methods Totally 80 weanling Wistar rats were equally divided into normal control (given with pure water and standard feed, including 1.15% calcium), lead group (given 1.0 g/L lead acetate water and standard feed), lead+low calcium group (1.0 g/L lead acetate water and feed including 0.69% calcium), and lead+high calcium group (1.0 g/L lead acetate water and feed including 1.72 % calcium). The development of rats was observed. Serum contents of osteocalcin and parathormone,and bone levels of lead and calcium in the femur were determined. The femur was examined with histological method. Another 5 Wistar rats received gastric irrigation of 10% lead acetate for 5 d, 5 more rats served as control, and then their absorption of calcium was detected with 45CaCl2. Results Lead and low calcium inhibited the development of rat remarkably, with the content of osteocalcin, the length and diameter of the femur decreased. High calcium antagonized these effects of lead. The absorption of calcium in rats was repressed by lead. Conclusion Bone depression by lead may be due to that lead inhibits the absorption of calcium in rats, and the supplement of calcium is helpful to minimize the repression.
