Effect of gadolinium chloride pretreatment on experimental hepatocarcinogenesis of H_(22) cells in mice
- VernacularTitle:氯化钆预处理对小鼠H_(22)实验性肝癌形成的影响
- Author:
Mengyuan WANG
;
Xiong DING
;
Jianping GONG
- Publication Type:Journal Article
- Keywords:
Chlorides;
Kupffer cells;
hepatoma
- From:Journal of Third Military Medical University
1988;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of gadolinium chloride (GdCl3) on the H22 experimental hepatocarcinogenesis in mice. Methods Totally 80 mice were inflicted to experimental hepatoma by implanting H22 cells to their liver lobes, and then equally and randomly divided into experimental hepatoma group (B) and GdCl3 pretreatment group (10 mg/kg, C). Another 40 mice served as normal control group (A). Ten mice from every group were killed respectively 7, 14, and 28 d after implantation. The left 10 mice were used for recording survival time and measuring the mass weight. Hepatic pathological histology was observed, and the expression of TNF-? was detected by ELISA and RT-PCR. Results ①Survival time was obviously higher in group B than in group C (P
