Relationship of endothelial nitric oxide synthase gene polymorphism with blood pressure, lipid profile and blood sugar level
- VernacularTitle:内皮细胞一氧化氮合成酶多态性与血压、血脂和血糖的关系研究
- Author:
Zhongzhi TANG
;
Junyao LI
;
Jianhong YANG
- Publication Type:Journal Article
- Keywords:
endothelial cells;
eNOS 298 Glu/Asp polymorphism;
hypertension;
serum lipid;
blood sugar
- From:Journal of Third Military Medical University
1988;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the relationship of the polymorphism of endothelial nitric oxide synthase (eNOS) gene and blood pressure, lipid profiles and blood sugar level. Methods Totally 184 essential hypertension patients and 196 matched health individuals with normal blood pressure were subjected in this study. Their age, sex and BMI were recorded and eNOS Glu 298 Asp gene polymorphism were detected in using PCR-RFLP. Lipid profiles, including triglycerides (TG), total cholesterol (CHO), HDL, LDL, and blood sugar level were also detected. Results Significant difference of the percentage of eNOS Glu 298 Asp gene were observed in age, systolic blood pressure, BMI group (P
