The Association of Polymorphism of Endothelial Nitric Oxide Synthase Gene in Patients with PAH of Chronic Obstructive Pulmonary Disease
- VernacularTitle:COPD肺动脉高压与内皮型一氧化氮合酶第4内含子VNTR多态相关性研究
- Author:
Yang GAO
;
Qiufeng WANG
;
Lirong SUN
;
Cong WANG
;
Shujun LI
- Publication Type:Journal Article
- Keywords:
COPD;
PAH;
Nos;
Polymorphism (genetics);
Minisatellite repeats
- From:
Journal of Medical Research
2006;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the variable number tandem repeats(VNTR)polymorphism in intron 4 of the endothelial nitric oxide synthase(eNos)gene and its relationship with plasma NO in patents with PAH of COPD.Methods The VNTR polymorphism in intron 4of the eNos genes of PAH COPD and healthy control were detected by PCR.The plasma level of NO3-/NO2-was measured by spectrophotometer,which was used as an index of NO synthesis.Data were analyzed according to the different genotype and allelic gene frequency.Results The COPD PAH group significant higher frequency of VNTR 4a allele and 4a/4b allele and 4a/4b+4a/4a genotype than those of the control(P=0.027,P
