Animal Experimental Study between the EDRF/NO And Endothelin in Regulative Relations
- VernacularTitle:内皮舒张因子和内皮素之间调控关系动物实验研究
- Author:
Aoli SUN
;
Yongbo SUN
;
Haifeng SUN
- Publication Type:Journal Article
- Keywords:
EDRF/NO;
Endothelin;
Perfusion;
Regulative relations
- From:
Journal of Medical Research
2006;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To probe into modulation effect between the EDRF/NO And ET.Methods In the whole Wister rat and rat's aorta perfusion model,they are carried through relative factors so that dynamic change of MABP,plasm ET-ir and cGMP level of tissue is observed.Results Whole Wister rat's experiment results:① In ET group,MABP first instantly(1~2min)reduces 6.58?0.67kPa,afterwards duratively enhances,it assumes the bidirectional response,when it reaches to 30min,MABP elevates 33.3?0.4kPa than before taking ET;Causes the aortic cGMP content to elevate,comparatively group control to increase 74.5%;② In L-NNA group,MABP slow rise,within 30min elevates to 4.62?2.04kPa;With control group comparison,the GMP level is reduced 5 times(0.42?0.08 versus the control 2.14?0.18pmol/mg Pr,P0.05);④ In Ach group,The vascular ET release reduces [406?31 versus control group 514?50pg/(g.w.w),P
