Ambroxol in the Rat Model of Bleomycin-induced Pulmonary Fibrosis and Its Possible Mechanism
- VernacularTitle:沐舒坦对大鼠肺纤维化模型的干预及可能机制
- Author:
Shuxian MIAO
;
Hong ZHAO
;
Yongshan YANG
;
Lina LI
;
Junying LIU
- Publication Type:Journal Article
- Keywords:
Ambroxol;
Pulmonary fibrosis;
Bleomycin;
Tumor necrosis factor-?
- From:
Journal of Medical Research
2006;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the therapeutic effect of ambroxol in bleomycin-induced pulmonary fibrosis of rats.Methods Sixty Wistar rats were divided into three groups:The normal control group(group N),the model group treated with bleomycinA5(group B)and the group treated with ambroxol(group A).Pulmonary fibrosis was induced by intratracheal instillation of bleomycin.Then the rats received daily ambroxol 35mg/kg(group A),or normal saline(group B).Five rats in each group were killed on 3.7.14 and 28 days after intratracheal instillation.Histological changes of the lungs were evaluated by HE stain and Masson's trichrome stain.The levels of tumor necrosis factor-?(TNF-?)in lung homogenates were measured by radioimmunoassay.Results Pulmonary fibrosis of Group A was significantly improved as compared with that of Group B(P
