Effects of two regimes of intensive insulin therapy for type 2 diabetes on improvement of the function of islet b cell
- VernacularTitle:两种胰岛素强化疗法对2型糖尿病人胰岛功能改善的比较
- Author:
Hua BAI
;
Danqing JING
;
Shinan YIN
- Publication Type:Journal Article
- Keywords:
insulin pump;
intensive therapy;
type 2 diabetes
- From:
Medical Journal of Chinese People's Liberation Army
1982;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of continuous subcutaneous insulin injection(CSII)and multiple subcutaneous insulin injection(MSII)on islet b cell function at the onset of type 2 diabetes.Method 64 patients were randomly divided into CSII(f/m=18/20)and MSII groups(f/m=14/12).There was no significant difference in age,fasting C peptide level,fasting blood glucose level,BMI and HbA1c.The patients of both groups were given intensive insulin therapy.Once the total dosage of daily insulin was kept less than 30U and the fast blood glucose was 3.6-6.0 mmol/L,intensive insulin therapy was changed to oral administration of hypoglycin A(OHA),otherwise the intensive insulin therapy was continued.The number of patients who were switched over to oral drug was compared after one month after the intensive therapy.Result 31 patients in CSII group and 8 patients in MSII group were changed to OHA one month after intensive therapy.A significant difference existed between the two groups(?2=3.37,P
