Reduction of Hugl-1 Gene Expression in NSCLC:Expression and Correlation with Clinicopathologic Parameters.
- VernacularTitle:人源幼虫巨大致死性基因在非小细胞肺癌中的表达及意义
- Author:
Yong YANG
;
Liangjian ZOU
;
Dong ZHOU
- Publication Type:Journal Article
- Keywords:
Non-small cell lung cancer(NSCLC);
Human lethal-giant lavae 1 (Hugl-1);
Tumor suppressor
- From:
Journal of Medical Research
2006;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective The aim of this study was to assess the expression of protein products of Hugl-1 (human lethal-giant-lavae 1)in non-small cell lung cancer(NSCLC), to estimate their possible expression and to correlate the results of immunohistochemical analysis with various clinicopathologic parameters. Methods The expression of Hugl-1 gene was detected by immunohistochemical S-P method in 50 cases of NSCLC tissues ,50 para-cancer tissues and 10 cases of lung benign lesion tissues as control. Results (1)The expression level of Hugl-1 gene was found to be significantly lower in NSCLC tissues than in para-cancer tissues and lung benign lesion tissues(P
