Study of Arsenic Trioxide and Cisplatin on Human Ovarian Cancer Cell.
- VernacularTitle:三氧化二砷、顺铂对人卵巢癌细胞联合作用研究
- Author:
Guohong YANG
;
Hua JIN
;
Ruifeng LIU
- Publication Type:Journal Article
- Keywords:
Arsenic trioxide;
Cisplatin;
Ovarian cancer;
Apoptosis
- From:
Journal of Medical Research
2006;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
2?mol/L) was obvious and the inhibitive degree was nearly 100% when the concentrations of arsenic trioxide and cisplatin were 12?mol/L and 4?mol/L. 2.Higher concentrations of arsenic trioxide and cisplatin perturbed cell through S-phase and up-regulated p53 gene expressions.Conclusions The inhibitive effect of arsenic trioxide combined with cisplatin was more obvious than either one used separately; the apoptosis mechanism of ovarian cancer cell line HO-8910 is related with perturbing of S phase and up-regulating of p53 gene expression.
