Effects of Tanggankang Capsule on Sugar fat Metabolizability and Liver Trauma of Diabetic Mice,Qianqiuhai,Lin Lan.
- VernacularTitle:糖肝康胶囊对糖尿病大鼠糖脂代谢及肝损伤影响的研究
- Author:
Yuexing XIAO
;
Qing NI
;
Qiuhai QIAN
;
Lan LIN
- Publication Type:Journal Article
- Keywords:
Diabetes;
Hepatic Injury;
Tanggankang capsule
- From:
Journal of Medical Research
2006;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effect of Tanggankang capsule treating liver trauma of diabetic mice.Methods Healthy Wistar rats are used in this trial. STZ are injected into the mice’s trail vein and they are fed with feed stuff with high quantity of heat. Eight weeks later, rats with blood sugar≥11.1mmol and disturbance of lipid metabolism are selected as diabetic model. 50 rats were randomly divided into five groups:low,moderate and high dosage groups;Metformin Hydrochloride and Glucurolactone control group。Every rat is given equal dosage by mouth once a day.After 6 weeks and 12 weeks, measure the blood sugar and lipid. At the 12th weeks, rats are sacrificed to weigh the liver and compute the liver coefficient and measure TC,LPO,ALT and AST. Results Tanggankang capsule has good therapeutic effect on treating hyperglycemia and disturbance of lipid metabolism for diabetic model; Tanggankang capsule can effectively prevent from the pathological change of diabetic fatty liver;what’s more,the more dosage and longer duration of drug,the stronger effect will appear,and the effect of large dosage is better than that of control group,thus the difference is remarkable (P
