Advances in study of glucocorticoid receptor induced insulin resistance and its antagonists
- VernacularTitle:糖皮质激素受体介导的胰岛素抵抗及其拮抗剂研究进展
- Author:
Ying LIANG
;
Qilong DING
- Publication Type:Journal Article
- Keywords:
glucocorticoid;
glucocorticoid receptor;
insulin resistance;
glucocorticoid receptor antagonist
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2000;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Glucocorticoids are among those most important hormones that maintain the energy metabolic homeostasis within body.The actions of glucocorticoids on target tissues,such as liver and adipose tissue,are not only dependent on circulating glucocorticoid levels but also on glucocorticoid receptor expression.The elevated level of circulating glucocorticoid caused by exogenous or endogenous reasons may contribute to insulin resistance and the other metabolic syndrome such as dyslipidemia,visceral obesity and hypertension.This review summarizes recent advances in the study of glucocorticoid receptor-mediated insulin resistance and its antagonists.
