Research advances on signal transduction pathways as therapy targets in gastric cancer
- VernacularTitle:胃癌信号转导通路治疗靶点的研究进展
- Author:
Lihui WANG
;
Jingyu YANG
;
Chunfu WU
- Publication Type:Journal Article
- Keywords:
gastric cancer;
signaling transduction pathway;
therapy target;
receptor tyrosine kinase;
cell cycle
- From:
Chinese Pharmacological Bulletin
1987;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
During the last forty years, although cytotoxic chemotherapy for gastric cancer patients has improved to some extent, its therapeutic effect is limited. Simultaneously, great progression of oncobiology to increase our understanding of the molecular basis of gastric cancer has been made. Currently the cancer cell has been characterized by several genetic changes that lead to altered cellular functions. In addition, multiple cancer-cell environment factors affect the tumor cell via various receptors and subsequent signaling pathways. The increasing knowledge of cellular signaling offers the opportunity to develop novel substances that target specific pathway molecules.
