Research progress of the methods and atrategies of introducing small interference RNA into mammals
- VernacularTitle:小干涉RNA导入哺乳动物体内的方法与策略研究进展
- Author:
Ailing FU
- Publication Type:Journal Article
- Keywords:
siRNA;
mammals;
delivery;
vector
- From:
Chinese Pharmacological Bulletin
1987;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Small interfering RNA (siRNA) is emerging as a powerful tool for in vivo research and for use as potential therapeutic agents. This review demonstrates the examples of the applications of siRNA as a new modality in gene therapy which can elicit down-regulation of gene expression and has prodigious potential in the treatment of diseases in mammals. Before siRNA technique is used in vivo, efficient strategies of delivery must be designed, such as vectors and routes of delivery. The problems that should be considered before applying this technology are outlined.
