Effect and mechanism of sodium aescinate on the brain edema induced by intracerebral hemorrhage in rats
- VernacularTitle:七叶皂苷钠抗大鼠脑出血后脑水肿作用及其机制
- Author:
Xiaoli XIE
;
Yunhui LIU
;
Yixue XUE
- Publication Type:Journal Article
- Keywords:
intracerebral hemorrhage;
brain edema;
occludin;
sodium aescinate
- From:
Chinese Pharmacological Bulletin
1987;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Aim To study the effect of sodium aescinate (10 mg?kg-1?d-1) on brain edema induced by intracerebral hemorrhage and the mechanism. Methods Male Wistar rats received an injection of 50 ?lautologous whole blood into the right basal ganglia and were killed 6, 24, 48 or 72 h later. Dry-wet-weighting technique, zymologic, immunohistochemical and Western blot methods were used to examine changes of water content, Na+ and K+ contents, glial fibrillary acidic protein(GFAP)-positive cells and expression of occludin, which is a tight junction(TJ)-associated protein. Results Compared with sham operation group, contents of water and Na+ were significantly higher(P
