Effect of rosiglitazone on the expression of integrin ?_1 in lung adenocarcinoma A549 cells
- VernacularTitle:罗格列酮对人肺腺癌A549细胞整合素?_1表达的影响
- Author:
Jie YANG
;
Yingzhi ZHUANG
;
Jianguo CAO
- Publication Type:Journal Article
- Keywords:
lung pulmonary carcinoma;
rosiglitazone;
integrin ?1
- From:
Chinese Pharmacological Bulletin
1987;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Aim To investigate the molecular mechanism of Rosiglitazone on the expression of integrin ?1 in lung pulmonary carcinoma A549 cell line. Methods RT-PCR and flow cytometry methods were used to examine the expression of mRNA and cell total protein of PPAR? and integrin ?1 subunit. Results The expression of PPAR? mRNA and integrin ?1 mRNA had dose-dependent regulating action by Rosiglitazone,using PPAR? inhibitor GW9662 and ERK pathway inhibitor PD98059 could abolish the inhibition of PPAR? on the expression of integrin ?1. Conclusion The effect of PPAR? ligand Rosiglitazone on integrin ?1 expression is mediated through PPAR?-dependent signaling parthway. The mechanism may be partly involved in ERK pathway.
