Discovery Strategy for Toxic-invited Constituents and Toxic-effective Substances on Chinese Material Medica Based on Processes of Metabolism and Disposition in Intra-body
- VernacularTitle:基于体内过程的中药毒性成分和毒性效应物质的发现策略
- Author:
Xiuwei YANG
- Publication Type:Journal Article
- Keywords:
processes of metabolism and disposition on Chinese material medica in intra-body;
toxic-invited constituents;
toxic-effective substances;
discovery strategy
- From:
China Journal of Traditional Chinese Medicine and Pharmacy
2005;0(02):-
- CountryChina
- Language:Chinese
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Abstract:
Chinese material medica is the natural therapeutic agent used under the guidance of the theories of traditional Chinese medicine.Its sources are mainly derived from plants,some derived from animals and minerals,and a few derived from chemical drugs and biologic products.It was made up into a colossal complex system because of its diversity of biological sources,ecological environments, chemical constituent structures,processing methods,processes of metabolism-disposition and their products in intra-body,biological activity and clinical use,and involved a lot of scientific problems.The elucidation of the toxic-invited constituents and toxic-effective substances is one of basic and scientific problem to clarify complex system of Chinese material medica.Along with the research progress of processes of metabolism and disposition of Chinese material medica in intra-body and metabonomics,a new and rapid-developing technology,the discovery strategy for toxic-invited constituents and toxic-effective substances on Chinese material medica based on the processes of metabolism and disposition would be made up,which will provide a new methodology and pathway to clarify of complex system of Chinese material medica.
