Effects of nordihydroguaiaretic acid on early embryo in rats
- VernacularTitle:去甲二氢愈创木酸对大鼠早期胚胎的影响
- Author:
Xiaohua WU
;
Lin WANG
;
Changxu SHI
- Publication Type:Journal Article
- Keywords:
nordihydroguaiaretic acid;
embryo;
deciduas
- From:Journal of Third Military Medical University
1983;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of nordihydroguaiaretic acid (NDGA) on the embryos growth and decidual development in rats. Methods Fifty pregnant SD rats were randomly divided into NDGA-treated group(N)and control group (P), which were given subcutaneous injection of NDGA or PBS on embryonic day 1(E1), E7 and E14, and then killed on E6 and E9. The number of implantations was calculated, the diameter of the embryos was measured and the numbers and weight of neonates were recorded. The expressions of VEGF, PCNA and FⅧRAg in the deciduas and embryos were detected by immunohistochemistry and then made image analysis. The serum concentrations of progesterone on E9 were measured. Results The number of implantations were decreased with NDGA treatment on E1 (P
