Study on adrenomedullin synthesized in alveolar macrophages in patients with chronic obstructive pulmonary disease
- VernacularTitle:慢性阻塞性肺疾病患者肺泡巨噬细胞合成肾上腺髓质素的研究
- Author:
Ping XU
;
Aiguo DAI
;
Yuanyuan LIU
- Publication Type:Journal Article
- Keywords:
Pulmonary disease,Chronic obstructive;
Adrenomedullin;
Macrophages
- From:
Chinese Journal of Practical Internal Medicine
2001;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects and mechanisms of adrenomedullin(ADM)synthesized in alveolar macrophages in patients with chronic obstructive pulmonary disease.Methods The bronchoalveolar lavagae fluids(BALF)were collected by bronchoscopy in 15 cases of COPD and 14 healthy cases.The expression of ADM in plasma,BALF and the culture supernatants of alveolar macrophages(AMs)were analysed by radioimmunoassay.Results (1)The cells,PMNs and AMs in BALF of COPD group were significantly higher than those of healthy group(P
