Expression of Fas/FasL and their significance in the pathological tissues of SARS patients
- VernacularTitle:严重急性呼吸综合征患者病变组织中凋亡相关基因Fas/FasL的表达及其意义
- Author:
Li HE
;
Qingling ZHANG
;
Yanqing DING
- Publication Type:Journal Article
- Keywords:
Severe acute respiratory syndrome;
Immunohistochemistry;
Fas/FasL;
Cell apoptosis
- From:
Chinese Journal of Practical Internal Medicine
2001;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the mechanisms and expressions of Fas/FasL in the lungs,spleens and lymph nodes of SARS patients.Methods The lungs,spleens and lymph nodes specimens of four autopsy cases and one control subject were studied with immunohistochemical mehod.Results Compared with normal tissues,apoptotic cells increased significantly in the spleens,lungs and lymph nodes of SARS patients.The apoptotic cells of lungs included alveolar epithelial ones,bronchial epithelial ones,monocytes/macrophages and lymphocytes.Apoptosis in the spleens and the lymph nodes was observed primarily in monocytes/macrophages and lymphocytes.Conclusion Over-expression of Fas/FasL is a general phenomenon in SARS,suggesting that Fas/FasL may play a key role in the pathogenesis of SARS.
