The influence of IFN on expression of chemokines IP-10,Mig in the patients with chronic hepatitis B
- VernacularTitle:慢性乙型肝炎患者外周血单个核细胞中趋化因子IP-10和Mig表达及其与干扰素治疗的相互关系
- Author:
Jinhong ZHAO
;
Jian WANG
;
Shuiqing JIANG
- Publication Type:Journal Article
- Keywords:
Hepatitis B;
Chemokine;
Interferon-?
- From:
Chinese Journal of Practical Internal Medicine
2001;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the levels of some CXC chemokines mRNA in patients with chronic hepatitis B and its changes after combinative treatment of two types interferon-?(IFN-?)with Ribavirin.The logarithm rate of chemokine/GAPDH was regarded as the extreme level of chemokine.Methods The different levels of IP-10 and Mig mRNA in peripheral blood mononuclear cells(PBMC)of chronic hepatitis B were kinetically detected by real-time polymerase chain reaction(real-time PCR)in different treatment stages.Results The expression levels of IP-10 and Mig mRNA in peripheral blood of patients were(0.7387?0.0768),(0.6883?0.0693),respectively.Which were significantly higher than that in normal controls(P
