Myocardial protective effect of adenosine during percutaneous coronary intervention
- VernacularTitle:经皮冠状动脉介入治疗中腺苷的心肌保护作用研究
- Author:
Zhenguo JI
;
Jianmiao HAN
;
Gang LIU
- Publication Type:Journal Article
- Keywords:
Coronary heart disease;
Angioplasty,transluminal,percutaneous coronary;
Adenosine
- From:
Chinese Journal of Practical Internal Medicine
2001;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the myocardial protective effects of intracoronary(IC)adenosine infusion in patients with coronary heart disease during percutaneous coronary intervention(PCI).Methods A total of 111 enrolled patients were randomised to receive infusions of saline(control group,55 patients)or adenosine(adenosine group,56 patients).10 mL saline(control group)or 300 ?g adenosine(adenosine group)was given by intracoronary(IC)injection within 1 minute.The peak level of ST-segment elevation in IC electrocardiograms(IC-ECG)and the peak level of cardiac triponin I(cTnI)was analyzed and left ventricular ejection fraction(LVEF)was measured.For the patients with acute myocardial infarction(AMI),coronary flow of the infract-related artery was assessed by the method of thrombolysis in myocardial infarction grading.The peak level of sum ST-segment resolution(STR)was measured after one hour of PCI.Results The peak level of serum cTnI in adenosine group was lower than the control group(P
