Study on the polymorphysm of MTHFR gene in coronary heart disease in Guizhou
- VernacularTitle:冠心病患者亚甲基四氢叶酸还原酶基因多态性87例研究
- Author:
Yan XIAO
;
Zhiheng HU
;
Keren SHAN
- Publication Type:Journal Article
- Keywords:
MTHFR;
Coronary heart disease;
Polymorphysm
- From:
Chinese Journal of Practical Internal Medicine
2001;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective Study on methylenetetrahydrofolate reductase(MTHFR)gene polymorphism in coronary heart disease.Methods Detect the MTHFR C677T gene polymorphism by PCR-RFLP in 73 cases of healthy individuals and 87 cases of coronary heart diseas(CHD).Results At the site of 677,the T allele frequencies are 18.5%,36.1%,respectively,for healthy individuals and 87 cases of coronary heart disease.The frequecies of MTHFR CT genotype and T allel were significantly higher in disease groups.There are significant differences between disease group and control group(P
