The effects of endogenous testosterone on early atherosclerosis of coronary artery in castrated rabbits
- VernacularTitle:内源性睾酮在去势雄兔早期动脉硬化中的作用
- Author:
Rong WANG
;
Li FAN
;
Xiaoying LI
- Publication Type:Journal Article
- Keywords:
androgens;
testosterone;
atherosclerosis;
hyperlipidemia
- From:
Medical Journal of Chinese People's Liberation Army
1983;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To determine the effects of endogenous testosterone on early atherosclerosis of coronary artery in castrated rabbits fed with high fat diet.Methods 30 adult male New Zealand white rabbits were randomly allocated to three groups:castrated group,physiological level group [6mg/kg intramuscular injection of testosterone undecanoate(TU)after cas tration,once every two weeks] and sham operation group.All animals were fed with high fat diet,but only the animals in both castrated group and physiological level group were castrated(bilateral castration)reproduce models with different testosterone levels.Serum total testosterone and estradiol,serum lipids and lipoproteins were determined 12 weeks after model establishment.The intimal thickness of coronary and kidney artery were measured and analyzed.Results The average level of serum TC,TG,LDL-C,ApoB,LDL-C/HDL-C and ApoB/ApoA1 were higher in castrated group than in sham operation group and physiological level group(P0.05).Conclusion The decrease in endogenous testosterone provokes early atherosclerosis of coronary artery in male rabbits fed with high fat eiet.
