Effects of esmolol on ATPase activity in myocardial mitochondria during cardiopulmonary resuscitation in rats
- VernacularTitle:艾司洛尔对心肺复苏大鼠心肌线粒体ATP酶活性的影响
- Author:
Yanying CHEN
;
Lingxin MENG
;
Youhai JIA
- Publication Type:Journal Article
- Keywords:
cardiopulmonary resuscitation;
propanolamines;
mitochondrial proton-translocating ATPases;
myocardium
- From:
Medical Journal of Chinese People's Liberation Army
1983;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of esmolol on ATPase activity in myocardial mitochondria after resuscitation in rats.Methods Sixty-six male Wistar rats were randomly allocated to three groups:sham group,AD group,AD+Es group.A cardiac arrest model was reproduced by asphyxiation in rats,and then CPR was performed in these animals after 10min asphyxia.The ATPase activity of myocardial mitochondria was determined at 30th,120th and 180th minute after resuscitation.ECG,MAP,HR and temperature were measured continuously.Results Heart rates were significantly higher after adrenaline when compared with sham group.Myocardial mitochondria ATPase activity was decreased significantly in both AD and AD+Es group compared with that of sham group(P
