Apoptosis and apoptosis-regulating genes in advanced breast cancer after preoperative regional intra-arterial chemotherapy
- VernacularTitle:术前区域性动脉灌注化疗对晚期乳腺癌细胞凋亡及相关基因表达的影响
- Author:
Jianmiao HE
;
Yongdong PU
;
Xiaojun MA
- Publication Type:Journal Article
- Keywords:
breast neoplasms;
drug therapy;
intra-arterial infusionchemotherapy;
apotosis;
genes,bcl-2;
genes,bax
- From:
Medical Journal of Chinese People's Liberation Army
1983;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of preoperative regional intra-arterial chemotherapy on apoptosis and apoptosis-regulating genes in advanced breast cancer.Methods 56 patients were divided into 2 groups:Preoperative regional intra-arterial chemotherapy group(treatment group,28 cases)and non-preoperative chemotherapy group(control group,28 cases).Apoptotic cells were examined by TUNEL and bcl-2 expression,and bax was detected by immunohistochemical techniques.Results Apoptotic index(AI)of breast cancer in the treatment group was 8.74%,while that of the control group was 4.65%.The bcl-2 expression in treatment group was 0.68?0.06,while in control group was 2.24?0.36.Expression of bax in treatment group was 0.72?0.06,while in control group was 0.38?0.04(P
