Alterations of von Willebrand factor and von Willebrand factor-cleaving protease activity in lung cancer patients and their clinical significance.
- VernacularTitle:血管性血友病因子及其裂解酶在肺癌患者中的表达及其意义
- Author:
Wei HENG
;
Zhaoyue WANG
;
Fang LIU
- Publication Type:Journal Article
- Keywords:
Lung neoplasms;
Von Willebrand factor;
Von Willebrand factor-cleaving protease
- From:
Chinese Journal of Practical Internal Medicine
2001;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To measure von Willebrand factor(vWF)concentrations and von Willebrand factor-cleaving protease(vWF-cp)activity in plasma of lung cancer patients and to evaluate their clinical significance.Methods The vWF:antigen(vWF:Ag)and vWF-cp activity were measured by using ELISA and residual-collagen binding assay(R-CBA),respectively in 78 patients with lung cancer.The serum and pleural fluid(PLF)of carcino-embryonic antigen(CEA)were measured by radioimmunity assay in 23 patients.Results (1)The level of vWF:Ag in lung cancer patients(107.7?43.7)%was significantly higher than that in benign diseases(71.3?49.5)% and normal controls(82.4?41.3)%(P
