Effect of ?-blocker atenolol on spatial dispersion of ventricular repolarization following acute myocardial ischemia.
- VernacularTitle:阿替洛尔对羊急性心肌缺血后心室复极离散度的影响
- Author:
Tongwen SUN
;
Lexin WANG
;
Fangxia GUAN
- Publication Type:Journal Article
- Keywords:
Ventricular repolarisation;
Dispersion;
Myocardial ischemia;
Atenolol
- From:
Chinese Journal of Practical Internal Medicine
2001;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of ?-blockers on spatial dispersion of ventricular repolarization following acute myocardial ischemia.Methods Twenty sheep were randomized into control(normal saline i.v.)and atenolol group.Acute myocardial ischemia was induced by occlusion of the obtuse marginal coronary artery.Unipolar ECG was simultaneously acquired from 64 epicardial sites in both ischemic and non-ischemic regions.Activation-recovery intervals(ARI)were determined from the epicardial ECGs.The difference between the longest and shortest ARI was defined as ARI dispersion.Results Ischemic zone in the atenolol group was less than that of the control group[(13?2)% vs (19?3)%,P
