Expression of fragile histidine triad gene and mismatch repair gene hMLH_1 in oral squamous cell carcinoma
- VernacularTitle:脆性组氨酸三聚体基因及错配修复基因hMLH_1在口腔鳞状细胞癌中的表达及意义
- Author:
Jianqi GU
;
Yinghuai ZHANG
;
Wei YANG
;
Jieying ZHANG
;
Chongbin JIANG
;
Zhiy JIA
- Publication Type:Journal Article
- Keywords:
oral squamous cell carcinoma;
fragile histidine triad;
mismatch repair gene hMLH_1;
immunohistochemistry
- From:Journal of Third Military Medical University
1984;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the expressions of fragile histidine triad (FHIT) and hMLH_1 in oral squamous cell carcinoma (OSCC) and their correlativity. Methods Immunohistochemistry was used to detect the expressions of FHIT and hMLH_1 in 69 OSCC and 40 normal oral mucosa. The data was analyzed by Chi-square test. Results The positive rate of FHIT and hMLH_1 in OSCC (46.4% and 47.8%) was lower than that in normal oral mucosa (77.5% and 77.5%), with statistically significant difference (P
