Correlation between VEGF-C/D expressions in tumor associated macrophages and lymph node metastasis in colon cancer
- VernacularTitle:结肠癌组织肿瘤相关巨噬细胞VEGF-C/D的表达及与淋巴结转移的关系
- Author:
Yan LI
;
Yong JIANG
;
Liqun SHI
;
Aixue SHI
;
Yiliang PENG
;
Houjie LIANG
- Publication Type:Journal Article
- Keywords:
VEGF-C;
VEGF-D;
tumor associated macrophage;
colon cancer
- From:Journal of Third Military Medical University
1984;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To discuss the correlation between the VEGF-C/D expressions in tumor associated macrophage (TAM) and lymph node metastasis in colon cancer. Methods Forty-five colon cancer samples proven pathologically to be adenocarcinoma were stained by immunohistochemical method for VEGF-C/D and CD68. The correlation of VEGF-C/D expressions, macrophage counting and lymph node metastasis were analyzed statistically. Results The expressions of VEGF-C/D were detected in TAMs. VEGF-C expression was obviously higher in the samples with lymphatic metastasis. VEGF-C expression in colon cancer was related to the number of TAMs. Conclusion TAMs are important in the lymph node metastasis, because they can express VEGF-C/D and affect the lymphangiogenesis of colon cancer.
