Electron Microscope Observation of Cardiomyocyte Apoptosis and Myocardial Change in Viral Myocarditis.
- VernacularTitle:病毒性心肌炎小鼠心肌细胞凋亡及心肌病变的电子显微镜观察
- Author:
Song ZHANG
;
Junbo GE
;
Bangfu RAO
- Publication Type:Journal Article
- Keywords:
Viral Myocarditis;
Apoptosis;
Electron microscope
- From:
Journal of Medical Research
2006;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study ultrastructure changes of myocardium and morphic change of cardiomyocyte apoptosis in mice with viral myocarditis(VMC).Methods Our experiment established animal model of VMC by the way of coxsackie virus B3(CVB3) inoculation,then we studied the changes and apoptosis of cardiomyocyte by ways of microscope and electron microscope.Results The myocardial changes and inflammatory cell infiltration were found by ways of microscope and electron microscope from 5 days after virus inoculation in experimental mice,the peak changes were at 7-9 days,and were almost recoverd at 35 days.Apoptotic changes and apoptotic bodies were found by eletron microscope at 7-9 days after virus inoculation in mice with VMC.Conclusions VMC can be caused in mice after CVB3 inoculation,abnormal cardiomyocyte apoptosis can be found in VMC.
