Algae Hepatotoxicity and Superoxide Dismutasd(SOD)Activity Induced by Mixture of Nickel Sulfate,Potassium Dichromate and Cobalt Chloride.
- VernacularTitle:鹅膏蕈及镍铬钴混合物对小鼠肝毒性及SOD活性影响
- Author:
Ji ZHOU
;
Yubai LI
- Publication Type:Journal Article
- Keywords:
Phalloides;
Nickel sulfate;
Potassium dichromate;
Cobalt chloride;
Hepatotoxicity;
Supetoxide dismutase
- From:
Journal of Medical Research
2006;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study hepatotoxicity and superoxide dismutase(SOD) acitvity produced by mixture of Nickel Sulfate,Potassium Dichromate and Cobalt Chloride.Mehtods Hepatotoxicity and superoxide dismutase(SOD)activity of mixture of Nickel Sulfate,Potassium Dichromate and Cobalt Chloride were detected by ip in mice.Results The liver weights were increased consistently during three weeds treatment.It was showed in histology study that hepatocytes swelling,necrosis and congestion wigh blood in venae interlobares hepatis.The SOD activity of liver and blood decreased after one week treatment but increased the following two weeks treatment.Conclusions Mixture of Nickel Sulfate,Potassium Dichromate and Cobalt Chloride had obvious hepatotoxicity and a certain lipid peroxiodation effect in vivo.
