Matrix metalloproteinases and nervous diseases
- VernacularTitle:基质金属蛋白酶与神经疾病
- Author:
Chao WEI
;
Zhenghong QIN
;
Huiling ZHANG
- Publication Type:Journal Article
- Keywords:
MMPs;
cerebra 1 ischemia;
Alzheimers disease;
multiple sclerosis;
Parkinsons disease
- From:
Chinese Pharmacological Bulletin
1987;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Matrix metalloproteinases (MMPs) are a family of Zn~ 2+ -dependent endopeptidases targeting extracellular matrix (ECM) compounds as well as a number of other proteins. Their proteolytic activity acts as an effector mechanism of tissue remodeling in physiologic and pathologic conditions, and as modulator of inflammation. Recently, it has been reported that MMPs play an important role in nervous diseases including cerebral ischemia, Alzheimers disease,multiple sclerosis and Parkinson′s disease.
