Glaucoma gene therapy:obstacles and challenges
- VernacularTitle:青光眼的基因治疗:问题与挑战
- Author:
Xiaoming CHEN
- Publication Type:Journal Article
- Keywords:
glaucoma;
gene therapy
- From:
Ophthalmology in China
1993;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Trabecular meshwork,ciliary body,retina and optic nerve will be the targets for glaucoma gene therapy.The strategies include lowering intraocular pressure,neuroprotection and preventing wound healing in glaucoma filtration surgery. Overexpression of certain gene(s)in trabecular meshwork to increase the resistance to aqueous humor outflow would be an ideal method to create an animal model of glaucoma.Even though great progress has been made in this field,significant challenges and obstacles, including lack of tissue specific promoter,problems in long-term gene expression and side effects,still remain to be resolved.
